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Brazil scientists capture images of monkeypox virus replicating

The virus is said to measure some 300 nanometers—0.00003 centimeters
Vinícius Lisboa
Published on 30/08/2022 - 10:37
Rio de Janeiro
03_A varíola dos macacos é transmitida pelo vírus monkeypox, que pertence ao gênero orthopoxvirus
© Débora F. Barreto-Vieira/IOC/Fiocruz

Scientists at Brazil’s research foundation Fiocruz were able to capture the moment in which a cell undergoes degeneration following an infection with the monkeypox virus. The magnification of the image up to 40 thousand times made it possible to see the viral particles replicating in the cytoplasm of the cell. 

According to the researchers, the monkeypox virus is estimated to measure 300 nanometers, or 0.00003 centimeters. Despite being 300 times smaller than the cell, the scientists believe it replicates easily enough to infect the cell.

The images were captured as part of a study on viral replication with a clinical sample from an infected patient who was put in contact with cells from the Vero lineage, often used for in-vitro assays and viral isolation.

The research is coordinated by the head of the Laboratory of Viral Morphology and Morphogenesis, Debora Ferreira Barreto Vieira, with Milene Dias Miranda, Gabriela Cardoso Caldas, and Vivian Ferreira on her team, in partnership with researchers from the Laboratory of Enteroviruses, an important authority in laboratory diagnosis for monkeypox among decision makers at the Ministry of Health.

Monkeypox has been declared an international public health emergency by the World Health Organization and has caused more than 40 thousand cases since the virus left the regions of the African continent where it used to be endemic.

The disease can be transmitted through close personal contact, such as kissing, hugging, and sexual intercourse, through contact with wounds, scabs, or body fluids, and also through respiratory secretions during prolonged personal contact. 

Symptoms may include skin lesions, fever, body aches, and headache. People with these symptoms should seek health care services and get tested.