The victory for Argentina, potentially star Lionel Messi's last official match at the Maracanã, ensures their dominance in the standings with 15 points.
The seleção did start off ahead, but underperformed at the Metropolitano stadium and were beaten 2–1 by Colombia in a match in the fifth round of the South American qualifiers for the 2026 World Cup.
Brazil's upcoming matches in South American qualifying will be against Colombia at Barranquilla's Estadio Metropolitano and Argentina at Rio de Janeiro's Maracanã.
Facing a resurgent Uruguay, coach Fernando Diniz must make adjustments to the starting lineup to secure victory away from home against a strong opponent.
CBF said it had accepted the agreement proposed by FIFA and the Argentine Football Association (AFA) not to carry out the game on September 22, in São Paulo.